- Jomo Kenyatta: Prime MinisterAs the leader of KANU, Jomo Kenyatta became Kenya's first Prime Minister in 1963 and later the first President. He was instrumental in negotiating Kenya's independence and shaping its political landscape. 
- Joseph Murumbi: Minister of State in the Prime Minister's OfficeJoseph Murumbi served as a crucial aide to the Prime Minister, managing key administrative and political functions within the Prime Minister's Office during a critical period of transition. 
- Tom Mboya: Minister for Justice and Constitutional AffairsTom Mboya, a charismatic and influential figure, held the vital portfolio of Minister for Justice and Constitutional Affairs. He played a significant role in shaping Kenya's legal framework. 
- James Gichuru: Minister for FinanceJames Gichuru was appointed as the Minister for Finance, responsible for managing Kenya's economy and financial policies during its formative years. 
- Dr. Julius Gikonyo Kiano: Minister for Commerce and IndustryDr. Julius Gikonyo Kiano held the post of Minister for Commerce and Industry, tasked with promoting trade and industrial development in the newly independent nation. 
- Bruce McKenzie: Minister for AgricultureBruce McKenzie, a controversial figure, served as the Minister for Agriculture. His role involved overseeing agricultural policies and development strategies. 
- Dawson Mwanyumba: Minister for Works, Communications and PowerDawson Mwanyumba was appointed Minister for Works, Communications, and Power, responsible for infrastructure development and essential services. 
- Samuel Ayodo: Minister for Local GovernmentSamuel Ayodo served as the Minister for Local Government, overseeing the administration and development of local authorities across Kenya. 
- Njoroge Mungai: Minister for Health and HousingNjoroge Mungai held the portfolio of Minister for Health and Housing, responsible for improving healthcare services and addressing housing needs. 
- Joseph Otiende: Minister for EducationJoseph Otiende was appointed as the Minister for Education, tasked with developing and implementing education policies for the new nation. 
- Ronald Ngala: Minister for Co-operatives and Social ServicesRonald Ngala, a prominent political figure, served as the Minister for Co-operatives and Social Services, focusing on community development and social welfare programs. 
- Daniel arap Moi: Minister for Home AffairsDaniel arap Moi, later to become President, was initially appointed as the Minister for Home Affairs, overseeing internal security and administration.